• Do not use EUTHYROX if you have uncorrected adrenal problems. • Use EUTHYROX only as directed by your prescriber. Take EUTHYROX as a single dose, preferably on an empty stomach, one-half to one hour before breakfast. • Tell your doctor if you are pregnant or breastfeeding or are thinking of becoming pregnant while taking EUTHYROX. Your dose of EUTHYROX may need to be increased during your pregnancy. • Taking too much levothyroxine has been associated with increased bone loss, especially in women after menopause. • Once your prescriber has found your specific EUTHYROX dose, it is important to have lab tests completed, as ordered by your doctor, to ensure that you are on the correct dose. • Talk with your healthcare provider about your diet as foods like soybean flour, cottonseed meal, walnuts, and dietary fiber may cause your body to absorb less EUTHYROX from the gastrointestinal tract. Grapefruit juice may cause your body to absorb less levothyroxine and may reduce its effect. If you eat these types of food, your dose of EUTHYROX may need to be adjusted. • Products such as iron and calcium supplements and antacids can lower your body’s ability to absorb levothyroxine, so EUTHYROX should be taken 4 hours before or after taking these products. • It may take several weeks before you notice an improvement in your symptoms. • Tell your doctor if you are taking any other drugs, including prescription and over-the-counter products. • Tell your doctor about any other medical conditions you may have, especially heart disease, diabetes, blood clotting problems, and adrenal or pituitary gland problems. The dose of other drugs you may be taking to control these conditions may have to be changed while you are taking EUTHYROX. If you have diabetes, check your blood sugar levels and/or the glucose in your urine, as ordered by your doctor, and immediately tell your doctor if there are any changes. If you are taking blood thinners, your blood clotting status should be checked frequently. • Tell your doctor or dentist that you are taking EUTHYROX before any surgery. • Tell your doctor if you develop any of the following symptoms: rapid or abnormal heartbeat, chest pain, shortness of breath, leg cramps, headache, nervousness, irritability, sleeplessness, shaking, change in appetite, weight gain or loss, vomiting, diarrhea, increased sweating, difficulty tolerating heat, fever, changes in menstrual periods, swollen red bumps on the skin (hives) or skin rash, or any other unusual medical event. • Partial hair loss may occur during the first few months you are taking EUTHYROX.